Lady-Vi® How it Works
What is TRANSDERMAL?
TRANS; meaning "across" ...... DERMAL; meaning "the skin"
Although we think of the primary purpose of the skin as a barrier to keep things out of the body, scientists have known for at least 2 centuries that certain compounds have the ability to cross the layers of the skin and obtain access to blood vessels and the general circulation. Modern medicine has responded with the development of methods to deliver drugs transdermally for therapeutic use as an alternative to traditional routes.
Why would one need to go through the trouble of formulating a transdermal when perhaps a simple tablet would do?
Well, the advantages of transdermal drug delivery systems speak for themselves and include avoidance of side effects, avoidance of the gastrointestinal tract and hepatic first-pass biotransformation and metabolism, control of absorption, availability of multiple skin sites to avoid local irritation and toxicity, and improved compliance.
arginine boosts sex and libido
Arginine has also been shown to act as a precursor in the body for nitric oxide. A gas molecule, nitric oxide has a number of potential effects on body cells, including the ability to relax arteries and small blood vessels. This can benefit sexual response by maintaining blood flow to the penis or clitoris, for example. Although researchers are still exploring its actions, there is some indication that nitric oxide may also function as a sex-enhancing neurotransmitter.
An inability to achieve arousal, difficulty having an orgasm, and other sex-related problems are widespread among Americans. The pharmaceutical industry has offered more help to men (Viagra) than women, but a recent study suggests that women experience an even higher rate of sexual dissatisfaction. The amino acid arginine may be a viable alternative to Viagra that is less expensive, causes fewer side effects, and is equally effective for men and women. Like Viagra, arginine increases blood flow to the genital area, potentially increasing sensation to the sex organs and enhancing the pleasures of lovemaking.
The main ingredient of Lady-Vi, l-arginine, is naturally occurring and one of the "semi-essential" amino acids, which increases blood flow through the major arterial blood vessels resulting in clitoral and labial engorgement.
In 1998 the Nobel Prize was awarded for the discovery that blood flow is regulated by a simple chemical called nitric oxide. Blood flow into the penis is what creates an erection. Blood flow into women's genitals increases sensation and orgasmic intensity. It works like this: The amino acid L-Arginine is used by the body to make nitric oxide. Nitric oxide turns on an important enzyme that creates Cyclic Guanosine Monophosphate (c-GMP.) This relaxes smooth muscle, the kind in your blood vessels, and allows for blood flow.
OF CLINICAL TRIALS
The study was a randomized, double-blind, placebo-controlled, three-way crossover clinical trial. Patients were 23 post-menopausal women who met DSM IV criteria for FSAD. The physiological sexual arousal of the subjects was measured by changes in vaginal pulse amplitude using a method called Vaginal Photoplethysmography.
The subjects were shown a neutral (non-sexual movie) as well as a film with sexual content. The degree of each subject's sexual reaction to the neutral as well as to the sexual movie was measured by the Vaginal Photoplethysmography technology. Subjective sexual arousal was also gauged by using a Self-Report Questionnaire that was standardized for all woman involved in the trial.
The results of the Vaginal Photoplethysmography showed a rapid and significant increase in Vaginal Pulse Amplitude Response (meaning the subject's degree of sexual stimulation) to the erotic film after the L-Arginine was administered as compared to the placebo group. The Self-Report Questionnaire yielded similar results. The study theorized that the mechanism responsible for the increase in sexual arousal was the body's enhanced production of Nitric Oxide due to the administration of L-Arginine.
The increased Nitric Oxide release caused the women who were given L-Arginine to be significantly more stimulated by the erotic content of the sexual film as opposed to those subjects who received the placebo.
References: Lebret, T., Herve, J.M, Barre, P., Lugagne, P.M & Botto, H. (2000). A controlled human trial. ESIR. Meston, C.M, Gorzalka, B.B, & Wright, J.M. (1997). Psychosomatic Medicine 59:399-407. Padma Nathan, H. (2000). ESIR. Simonsen, U. Prieto, D., Hernadez, M., Saenz de Tejada, I., & Garcia-Sacristan, A. (1997). 157: 2356-2360.
The results of another clinical study of L-Arginine were presented at the Ninth Annual Congress on Women's Health & Gender-Based Medicine in Washington, D.C. The study indicated significant improvement in women's sexual desire and overall satisfaction. In this double-blind placebo-controlled study, 93 women, ages 22-73, enrolled as participants lacking sexual desire.
Of the 93 women involved, 46 received L-Arginine and 47 received a placebo. The participants used a Female Sexual Function Index Questionnaire to rate their level of sexual health before starting the study and after taking either a placebo or the L-Arginine.
At the end of four weeks, 62 percent of the active group reported significantly improved satisfaction with their overall sex life and 64 percent reported an improvement in their level of sexual desire.
REFERENCES: Mary Lake Polan, MD, PhD, MPH, Professor and Chair, Department Of Gynecology/Obstetrics, Stanford University School of Medicine. Study results published in the May/June issue of the peer-reviewed, "Journal of Women's Health and Gender-Based Medicine".
Numerous studies over the past decade have explored the role of nitric oxide in sexual response. Nitric oxide has been shown to increase erections, for example, in primates, dogs, cats, rats, rabbits, and other animals. Animal studies have also determined that long-term oral administration of arginine has potentially beneficial effects on erectile response. As one study concluded, "These data support the possible use of dietary supplements for treatment of erectile dysfunction." A few animal studies have also shown beneficial effects for both nitric oxide and arginine on female sexual response.
A more limited number of studies have looked directly at the effects of arginine on human sexual response. For example, a small 1994 study in which men took 2.8 grams of arginine every day for two weeks showed a significant improvement in erectile function. Another study found that almost three-quarters of 178 men with low sperm counts had significantly higher counts after taking 4 grams of arginine daily for at least three months. Most recently, a study published in 1999 followed 50 men with erectile dysfunction for six weeks. Among those who took a high (5 grams) daily dose of arginine, 31 percent reported significant subjective improvements in sexual function, compared to only 12 percent of those taking a placebo. Human studies on arginine for women seem to be lacking at this point.
problems on the rise
One of the most popular new drugs in recent years, Viagra targets sexual dysfunction, though the FDA currently approves its use only for men. (Physicians are free to prescribe it "off-label" for women.) Although Viagra does reduce erectile problems, its adverse side effects include migraines, blurred vision, sinus congestion, and even a potentially fatal sudden drop in blood pressure. Viagra's usefulness for women is under study, with only a few (mostly conflicting) trials being done so far. Unfortunately, compared to men, women may be even more susceptible to Viagra's side effects.
Clearly, safe and effective alternatives to drugs like Viagra would benefit many people. The amino acid arginine may be just what the natural doctor ordered.
Arginine is often referred to as L-arginine, which is the natural L (or levo-rotatory) form. One of the best ways to maintain "NO" levels is to make sure enough arginine is consumed. Lady-Vi was formulated to provide L-arginine to various parts of the body, to help ensure adequate levels of NO. Arginine is a component of many foods such as milk, meat, chicken and fish and has many other health-supporting benefits. It is essential in processes involving neurotransmitters, which carry messages between brain cells. It is a free radical scavenger and supports immune function, the maintenance of normal viscosity of the blood, the relaxation of blood vessels, and blood flow to the male and female sex organs.An amazing amino acid. The diversification of arginine actions. Increases nitric Oxide (NO) levels , NO is a gas molecule that acts as a chemical messenger for numerous functions in the body. It signals the release of important hormones and acts as a neurotransmitter in the brain. It is used by the immune system to kill marauding bacteria and cancer cells. Adequate levels of NO normalize blood pressure, prevent heart disease, and maintain good circulation. NO is even involved in the formation of erections. It protects the endothelial cells lining the arteries from the initial adherence of plaque. It is an important antioxidant, guarding LDL cholesterol from free radical damage that transforms it from a benign blood fat to an aggressive artery blocker. It also prevents platets in the blood from sticking together, deceasing the formation of clots that might imitate a heart attack. In addition, NO relaxes the arteries and prevent arterial spasms. Arginine has been shown to actually restore normal function in arteries damaged by LDL cholesterol. Arginine signals the smooth muscle cells of the arteries to relax, thus increasing their diameter, by allowing blood to flow more freely, with less pressure against arterial walls, NO is a primary regulator of blood pressure.
goes beyond Viagra's capability because it improves cardiovascular
function, thereby enabling restoration of arterial health, upon
which an important mechanism for sex is based. In addition, arginine
acts as a growth hormone releaser. It enhances muscle mass and
tone, as well as memory and immune function. Unlike the drug Viagra,
arginine is a natural nutrient that is safe and essential, without
Since Viagra first became available, many women have reported that it works as well for them as for their male partners. Anecdotally as well, many women have said the same about arginine. Reports claim greater lubrication, more sensitivity, and increased ease, frequency, and intensity of orgasm.
L-Arginine - the key ingredient that your body needs to restore, stimulate, and help maximize your sexual response and overall sex drive. The presence of L-Arginine in the clitoris and surrounding tissue is vital to the proper functioning and maximum arousal of the clitoris.
As a woman is sexually stimulated, the brain signals the Pudendal Nerve and the Clitoral Nerve (the nerves responsible for vaginal sexual sensations). Once activated, these nerves convert available L-Arginine into nitric oxide and nitric oxide draws blood into the area causing the clitoris to become full, aroused and highly sensitive.
Lady-Vi cream delivers L-Arginine directly to where it is needed, accelerating and intensifying the effects of sexual stimulation.
Daily applications of Lady-Vi to the clitoris and surrounding areas maximizes the presence of L-Arginine, which helps to increase the production of nitric oxide during sexual encounters. The presence of nitric oxide increases the blood flow to the clitoris, enhancing clitoral stimulation and the sexual experience.
So how does arginine work in women? NO (Nitric Oxide) has been found to be produced in clitoral tissue. This means that the same kind of hampered blood flow that causes erectile difficulties in men may be the cause of many cases of impaired female sexual response. Moreover, levels of nitric oxide have been found to decline rapidly in women as they age. Thus, women may need to boost NO levels, which they can do by supplementing with arginine naturally. Viagra cannot make NO. Furthermore, the prescription drug Viagra is foreign to the body and has a spectrum of significant side effects, some of which have been reported to be associated with numerous deaths. Viagra is also considerably more costly than arginine.
Good circulation is important for optimum health. The blood vessels must stay open to permit efficient blood flow. Constriction of blood vessels, which can be brought about by such factors as stress and stimulants such as caffeine, certain drugs, and nicotine, can work against healthy circulation. Plaque can reduce flexibility of arterial walls and the opening size where blood flows. "Nitric Oxide" sounds like a toxic chemical, but it is a natural substance that is a combination of Nitrogen and Oxygen.
body makes "NO" from arginine, a natural amino acid, a component
of most proteins we eat. It is also referred to as "ADNO," an
abbreviation for "Arginine Derived Nitric Oxide." ADNO is used
by the body to support the normal vasodilation-the process, which
keeps the arteries open.Arginine is totally natural, not a hormone,
and supports normal body processes. Over 10,000 scientific papers,
which document the benefits of "NO" have been published in numerous
scientific journals around the world. They include prestigious
publications such as the Journal of the American Medical Association,
Lancet, The New England Journal of Medicine,
To achieve reliable sexual function, you must have good circulation. The blood flow into the penis fills the vessels and expands the tissues under pressure to create a firm erection. The female clitoris functions the same way. Difficulty in achieving an erection for the 80% of men who have the problem can be linked to physical or nervous conditions, drugs, or reduced blood flow to the area.
Lady-Vi is not a drug like Viagra®, it is a natural nutrient that supports the body's production of "NO". It is interesting that research which led to the popular drug Viagra®* was based on extending the life of "NO" in the body.
Sexual responsiveness requires adequate blood flow to the vagina and especially the clitoris. It follows that when women are unable to achieve orgasm or have delayed orgasms or suffer from vaginal dryness, these problems are likely to be due to insufficient or poor blood flow to the genital area. A variety of factors can cause poor circulation, such as heart disease, diabetes, or too much cholesterol. Smoking, a bad diet, lack of exercise, and a wide variety of drugs can also cause circulatory problems.
Unfortunately, there are far fewer answers to questions about sexual dysfunction in women than in men, because they are not as frequently the subjects of studies. Although there may be as many as 60 million American men with erectile problems ranging from occasional to complete dysfunction, comparable figures have not been compiled for women.
Undoubtedly, however, answers are on the way. But rather than wait for the needlessly gloomy finding, women will not settle for second-class responsiveness. Given a clear choice, women will progress beyond drugs like Viagra, which are not long-term solutions for the restoration of their sexual health. Whatever they choose, the chances are good that they will take NO for their answer.
But unlike Viagra, arginine is reported to increase sexual desire (libido). This is probably because NO, also made from arginine in the brain, operates as a neurotransmitter involved in the creation of long-term memory. Indeed, studies have shown that memory and libido are connected. In women, they decline with age, but when sex hormones such as testosterone are replaced, both memory and libido increase. At least one study has reported that testosterone maintains the erectile response by alternate pathways, including one that is independent of NO. Alternatively, when NO is abundant, it may be that more testosterone is available for increasing libido. Other research indicates that NO enhances the ability to remember sex scents (pheromones), which are intimately related to libido.
FYI: Why do guys wake
up with a hard on? My boyfriend wakes up with a hard-on every morning
but says he's not always aroused because of it. Why do guys get this